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Symbol
Name
ID

Sirt1
sirtuin 1
MGI:2135607

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Gliosis	Cerebellar atrophy	Neuronal loss in central nervous system	Gait ataxia	Bradykinesia	Chorea	Depression	Personality changes	Dementia	Hyperreflexia	Seizure
Disease(s) Associated with SIRT1
Huntington's disease

Mouse Phenotypes		decreased pituitary gland weight	small pituitary gland	abnormal pituitary gland physiology	decreased brain weight	exencephaly	abnormal retina photoreceptor morphology
Availability	Mouse Genotype	decreased pituitary gland weight	small pituitary gland	abnormal pituitary gland physiology	decreased brain weight	exencephaly	abnormal retina photoreceptor morphology
	Sirt1^tm1Fwa/Sirt1^tm1Fwa
	Sirt1^tm1Mcby/Sirt1^tm1Mcby
	Sirt1^tm1.1Cxd/Sirt1⁺
	Sirt1^tm3Fwa/Sirt1^tm3Fwa Tg(Nes-cre)1Kln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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